"No one is illegal on stolen land," she said while accepting the award for the song from her 2024 album Hit Me Hard and Soft.
"F**k ICE is all I want to say."
Immigration became a pointed theme at the 68th annual Grammy Awards.
Bad Bunny, after winning an award for his zeitgeist-shaping album Debí Tirar Más Fotos in the música urbana album category, also used his speech to share an anti-ICE message, highlighting the humanity of all people.
"Before I say thanks to God, I'm going to say ICE out," he said, starting out his speech in English to huge applause.
Bad Bunny said that love is the only thing more powerful than hate and urged people to confront cruelty with compassion.
"We love our people. We love our family," he added.
"We're not savage, we're not animals, we're not aliens. We are humans and we are Americans."
Before that, Olivia Dean clinched the Grammy for best new artist in a milestone moment for the British pop singer-songwriter known for her soulful voice and timeless sound.
"I never really imagined that I would be up here," she said, receiving her first Grammy while wiping away tears.
"I'm up here as a granddaughter of an immigrant. I wouldn't be here ... I am a product of bravery and I think that those people deserve to be celebrated."
The hits arrived fast and furious in the show's first hour on Sunday (Monday AEDT) at Los Angeles' Crypto.com Arena.
Rosé and Bruno Mars' opened the 68th annual Grammys with an electric rendition of their multicultural pop smash, APT.
The Blackpink singer channelled a pop-punk Gwen Stefani in her tie and platinum blond hair. Sabrina Carpenter with her Manchild kiss-off. Justin Bieber slowed things down with Yukon from his comeback record Swag.
Host Trevor Noah opened with a speech celebrating the incredible breadth of talent nominated this year while poking fun at them - at one juncture, joking that Jelly Roll and Teddy Swims should be able to unlock each other's phones, given their similar face tattoos.
Noah is hosting the Grammy Awards for a sixth and final time live from Los Angeles' Crypto.com Arena.
The first award of the televised show went to Kendrick Lamar for rap album GNX, presented by Queen Latifah and Doechii.
"It's an honour to be here," he said in his acceptance speech. "Hip-hop is always going to be right here ... We're gonna be having the culture with us."
The victory means Lamar broke Jay-Z's record to become the rapper with the most career Grammys. Jay-Z has 25; after he took home rap album, Lamar's total is 26.
Australian artist Tame Impala picked up his first solo Grammy for the Best Dance Electronic Recording during the Premiere Ceremony held at the adjacent Peacock Theater in Los Angeles ahead of the main show.
Lady Gaga won best pop vocal album for Mayhem.
"I've been making music since I was a little girl and every time I'm here, I still feel like I need to pinch myself," she said.
The Dalai Lama also won his first Grammy for audio book, narration and storytelling recording, beating out Supreme Court Justice Ketanji Brown Jackson.
Veteran film director Steven Spielberg won a Grammy to add to his trophy cabinet, making him an EGOT winner - an artist with an Emmy, Grammy, Tony and Oscar.
Spielberg received the Grammy for best music film category for producing the documentary Music by John Williams, with the trophy handed out during the non-televised premiere ceremony.
Yungblud won his first Grammy for rock performance for his cover of Black Sabbath's Changes (live from Villa Park), which he performed at Ozzy Osbourne's final show. Hardcore band Turnstile also won their first Grammy for rock album and later, metal performance.
"To Baltimore, thank you, we love you," said frontman Brendan Yates.
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