Prosecutor Riel Karmy-Jones said six different women who do not know each other had come forward to accuse Brand of attacking them over the course of a decade.
In her closing speech, she told jurors the women had not been compelled to come forward by a "magic force" of media reporting on Brand's alleged misconduct but had instead been seeking "closure" by speaking to police.
Their encounters with Brand had "haunted them for years," Karmy-Jones said and she pointed out they described a similar pattern of behaviour from the British comedian that started with compliments, flattery and flirting before a "personality change".
"His eyes changed, he snapped, from charming to frightening to nasty," she said.
The prosecutor said the women had claimed Brand "didn't listen when (they) said no, he didn't stop, he didn't care, pulling, pushing, tugging, thrusting".
"In the rape cases, he kept on going until he achieved his ultimate aim."
The prosecutor also pointed jurors to several accounts by the women of Brand giving them his phone number or email address in the aftermath of the alleged attacks.
"Today it's something that might be known as gaslighting," she said.
"A technique the defendant used to good effect."
Brand denies three counts of rape, three counts of sexual assault and one charge of attempted indecent assault.
"In this trial you have seen six different women, wholly unconnected with each other, come before you and tell you what happened to them at the hands of Russell Brand," Karmy-Jones told jurors.
"These women who finally made their decision to speak, call police, are wholly independent of each other. They don't even know who the other women in this case are."
An MTV worker has accused Brand of trying to drag her into a toilet at work in 2001 when he was one of the channel's star presenters but she said she managed to wrench herself away.
She gave evidence that the incident lasted for 20 seconds, and the prosecutor pulled out a stopwatch during her speech on Friday to show jurors how long the incident had lasted.
The court fell silent for 20 seconds as the prosecutor told jurors to "take a moment" and imagine how long the woman said she was "being pulled into a lavatory".
At the end, she said: "Pulling, not just a gentle grab of the arm and a 'come in'. Twenty seconds of this."
Brand gave evidence on Wednesday, saying consent is "more important than sex itself" and denying forcing any of the women into sexual activity.
He told the court it was "devastating" when he was first accused of rape and sexual misconduct in 2023 media reporting by The Times, The Sunday Times and Channel 4 Dispatches.
The trial continues.
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