House is the first track released from Charli XCX's score for Emerald Fennel's film adaption of Emily Bronte novel Wuthering Heights, and features a spoken word part from Cale accompanied by his signature harsh viola, before a screamed chorus of "I think I'm gonna die in this house".
Announcing the song, the 33-year-old singer said in a post on Instagram that she was a "huge fan" of the Lou Reed-led band.
She said she was inspired by Todd Haynes's 2021 documentary about the legendary New York band, and the way Cale described their need to create songs that were both "elegant and brutal".
"We got connected, we spoke on the phone and wow... that voice, so elegant, so brutal, I sent him some songs and we started talking specifically about House.
"We spoke about the idea of a poem. He recorded something and sent it to me. Something that only John could do. And it was... well, it made me cry."
A video for the new single shows Charli lying in a bed in a house in the forest as 83-year-old Cale stands over her reciting his lines, before putting his hand on her head as a raven flies away.
In her Instagram post, Charli added: "After being so in the depths of my previous album (2024's Brat) I was excited to escape into something entirely new, entirely opposite.
"When I think of Wuthering Heights I think of many things. I think of passion and pain. I think of England. I think of the Moors, I think of the mud and the cold. I think of determination and grit."