Culkin said "I feel such esteem from this whole thing" as he received his star on Friday in the category of Motion Pictures, with guests including Paris Jackson, Catherine O'Hara, Natasha Lyonne, and his siblings Quinn and Rory.
The 43-year-old began his stage career at the age of four in Rocket Gibraltar playing the grandson of Burt Lancaster, before rising to stardom in John Hughes' Home Alone playing Kevin McCallister which won him a Golden Globe nomination.
Macaulay Culkin gained worldwide fame after starring in the movie Home Alone. (AP PHOTO)
"There's so many people that I love and to feel that love back is just amazing," he said.
He continued: "I'd like to thank Brenda, you're absolutely everything. You're my champion, you're the only person happier for me today than I am.
"You're not only the best one I've ever known, you're the best person I've ever known.
"You've given me just all my purpose, you've given me family and after the birth of our two boys, you've become one of my three favourite people."
Culkin ended his speech referencing a beloved quote from Home Alone: "To wrap things up in the spirit of the holiday season, I just want to say 'Merry Christmas, ya filthy animals!'"
O'Hara, who played Culkin's onscreen mother in the Home Alone franchise, said "I am so proud of you" when taking to the stage to honour the former child star.
She said: "The reason families all over the world can't let a year go by without watching and loving Home Alone together, is because of Macaulay Culkin.
"It is Macaulay's perfect performance as Kevin McCallister that gave us that little every boy on an extraordinary adventure.
"I know you worked really hard but you made acting look like the most natural thing in the world to do, it really was as if we had ambushed the home of this real little boy named Kevin to make a movie and he just went along with it for the fun of it."
While Orange Is The New Black star Lyonne, who met Culkin during filming Party Monster in the early 2000s, said "There's a very rare unspoken language that happens between child actors who make it out alive".
"And so we find each other, and we instinctively register what a miracle that survival is.
"The true beauty though, is seeing the adult you've become, the loving patriarch you are to your beautiful siblings, and now the deep and loving father and husband that you are."
