The 43-year-old will perform shows in London, Paris and Dublin, after he was removed as a support act for Sheeran in the US over comments he made about Gaza.
Since then, all of Sheeran's Loop Tour supporting acts, including Irish singer Aaron Rowe, Grammy award-winning musician Finneas, who is Billie Eilish's brother, and Danish singer Lukas Graham, as well as his backing band Beoga, have dropped out of the remaining dates.
On Thursday, Macklemore announced that he would bring together artists and friends for a series of performances to help provide humanitarian aid and support for people in Palestine.
"If these last couple of weeks have shown us anything, it's that something has shifted over the last three years," he wrote on Instagram.
"There has been a collective awakening around Palestinian liberation, the power of billionaires that try to censor that call, and what we expect from artists right now.
"It's 2026. Being apolitical during a genocide doesn't work anymore. People are asking artists to show up, educate themselves and be in community.
"To use the stage for more than entertainment. To push back when the call for a Free Palestine is met with attempts to silence it."
Robert Kraft, whose Kraft Group owns the Gillette Stadium in Massachusetts, was among the people who contacted Sheeran and told him they would not be able to play the venue unless the rapper was removed from the US tour.
Sheeran said it was the promoter's decision to remove Macklemore from the tour and not his.
Macklemore's tour will kick off in Dublin's 3Arena on October 26 followed by Paris Accor Arena on October 29 and wrap up at London's Wembley Arena on October 30.
All the proceeds from the concerts will go towards a number of organisations working in support of Palestinian people including medical care, humanitarian assistance, education, community support and advocacy.
Those organisations include Anera, Glia, Gaza Soup Kitchen, Taawon, Heal Palestine, Palestinian Youth Movement, Middle East Children's Alliance, Jewish Voice for Peace, Medical Aid for Palestinians, Institute for Middle East Understanding, Palestine Children's Relief Fund and UNRWA USA.
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