Comic Nate Bargatze will be a first-time host on Sunday night (10am on Monday AEST) when the ceremony at the Peacock Theater in Los Angeles gets underway
Apple TV+ is poised to have a breakout Emmy year with the two most nominated shows, Severance and The Studio, which are the favourites to win the two biggest awards.
Cate Blanchett is among a group of Australians vying for honours, being nominated for outstanding lead actress in another Apple TV+ series, Disclaimer.
Australian director Shannon Murphy is also in line for the FX series Dying for Sex and and Zoë White is nominated for outstanding cinematography for the Netflix series Will & Harper.
Australian producers Karina Holden and her colleague Cian O'Clery have already won two Emmys at the Creative Arts awards which celebrate technical and artistic achievements, for the US version of their groundbreaking dating series Love on The Spectrum.
The Studio, with co-creator Seth Rogen starring as the new head of a movie studio, comes into the evening with blockbuster buzz for its breakout first season.
It tied a record for a comedy with 23 nominations, and with nine Emmys already won at last weekend's Creative Arts ceremony, it would be a major surprise if it did not break the record of 11 Emmy wins in a season by a comedy.
It could win as many as 15, and Rogen himself could win four times, as an actor, a writer a director and an executive producer.
The Bear and Hacks which have dominated the comedy Emmys in recent years, are both again up for best comedy series but suddenly find themselves underdogs.
Severance, the Orwellian office drama about people who surgically split their psyches into workplace "innies" and home "outies", was the top overall nominee with 27 nominations for its second season. It won six at the Creative Arts ceremony.
Along with best drama it's nominated in all four dramatic acting categories, with stars Adam Scott and Britt Lower each looking for their first Emmys.
Its top competition for best drama could be The Pitt, HBO's acclaimed drama about one shift in the life of an emergency room.
Its star Noah Wyle could be both the sentimental favourite and the actual favourite for best actor. He was nominated five times without a win for playing a young doctor on ER in the 1990s, and now could finally take his trophy for what is in many ways a reprise of the role.
HBO's prestige resort soap The White Lotus could also be in the mix for best drama its Thailand-set third season and has three nominees apiece in each of the drama supporting acting categories.
It could be an unprecedented night of Hollywood recognition for older women in an industry known for discarding female actors.
Oscar-winner Kathy Bates at 78 could become the oldest winner ever in the best actress in a drama category for playing the title role in CBS' Matlock. She'd be the first woman from a network series to win the award in a decade.
And Jean Smart at 73 could extend her own record for oldest winner of best actress in a comedy if she wins for Hacks as she has for all three previous seasons of the show.
Netflix's Adolescence, the story of a 13-year-old in Britain accused of a killing whose four episodes each take place in one continuous shot, may be the year's most acclaimed show and is the consensus favourite for best limited series. Fifteen-year-old Owen Cooper could become the youngest Emmy winner in more than 40 years for playing the accused boy.
