The fifth-placed Hurricanes are 'hosting' the clash at Marvel Stadium after the league rejigged its fixtures in an attempt to limit the impact of COVID-19.
Hobart will secure the last of five spots in the competition's post-season if they win on Tuesday night.
Hurricanes star Ben McDermott produced a stunning knock of 127 earlier this season against the Renegades at the same venue.
Indian batter Unmukt Chand is making his BBL debut for the bottom-placed Renegades.
The Board of Control for Cricket in India (BCCI) blocks its male players from taking part in other nations' Twenty20 leagues.
But Chand, who captained India at under-19 level, no longer plays under the BCCI's umbrella.
TEAMS
Hobart Hurricanes XI: Ben McDermott, Josh Kann, Matthew Wade (capt), D'Arcy Short, Tim David, Caleb Jewell, Peter Handscomb, Jordan Thompson, Tom Rogers, Riley Meredith, Sandeep Lamichhane.
Melbourne Renegades XI: Aaron Finch (capt), James Seymour, Shaun Marsh, Unmukt Chand, Jono Merlo, Sam Harper, Will Sutherland, Cameron Boyce, Zak Evans, Josh Lalor, Zahir Khan.
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