Iran meet Australia in their second Women's Asian Cup group-stage match on Thursday on the Gold Coast after opening their tournament with a defeat to South Korea on Monday.
Iran's 3-0 loss to the Koreans came a little more than 48 hours after US-Israeli rocket attacks killed Iran's leader Ayatollah Ali Khamenei.
As well as the assassination of Khamenei, the Iranian Red Crescent claims more than 500 civilians have been killed in the attacks.
Iran's players and coach Marziyeh Jafari have so far refused to comment on the military attacks or the death of their country's long-serving leader.
The Iranian team did not sing the national anthem during the loss to South Korea.
Sayer claims the Iranian squad deserve sympathy and respect for continuing to play while the conflict engulfing their nation intensifies.
"Our heart goes out to them and their families, it's a difficult situation and it's really brave of them to be able to be here and to perform," Sayer told reporters on Tuesday.
"They played last night (on Monday) and they put on a really strong performance, even with the political climate that's going on and the struggles that they might be going through.
"I think we're excited and looking forward to the game on Thursday … The best we can do to contribute is to just give them the best game of football that we're able and to show them the respect on the field.
"Hopefully the situation improves and they can keep staying safe in Australia."
There were fears Iran would not take part in the tournament when a series of protests sparked civil unrest in January earlier this year.
The Iranians arrived on the Gold Coast last week and are sharing a hotel with the Matildas in the lead-up to Thursday's game.
"Whenever we do come across them we'll be able to say a cordial 'hello' and be able to give them our words of sympathy," Sayer said.
"They are another team in the tournament and you don't want to give them any space in order to give away any competitive advantage, regardless of the situation.
"Of course, we are all kind humans, and we can give them a 'hello' and a 'good luck' to wish them well."
Sayer is likely to feature more heavily against Iran after being given a late cameo off the bench in Sunday's win over the Philippines in Perth.
The 24-year-old has long been touted as a mainstay of the Matildas but was robbed of a place at the Paris Olympics after sustaining an anterior cruciate ligament injury.
"It didn't quite feel like such a momentous occasion, but it was my first major tournament debut," Sayer said.
"Regardless of whether I'm starting or on the bench, I'm still giving 110 per cent in every training session and in all the warm-ups in order to make sure that we come away with the trophy."
Australia's squad trained in full on Tuesday with Kyra Cooney-Cross seen alongside her Matildas teammates for the first time.
Cooney-Cross has barely played for club side Arsenal since the turn of the year following her mother's cancer diagnosis and the midfielder did not feature against the Philippines.
No.1 Mackenzie Arnold was also back among her fellow goalkeepers after battling a calf issue that prevented her from taking the field in last Sunday's tournament opener.
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