Alex Valle had put Champions League hopefuls Como ahead in Sunday's match and Nico Paz doubled the lead just before half-time with a low strike into the far corner.
Inter, though, quickly pulled a goal back through Marcus Thuram in added time ahead of the break.
Thuram then equalised four minutes into the second half with a chipped finish from the edge of the box over stranded Como goalkeeper Jean Butez.
Denzel Dumfries completed the turnaround just before the hour when he headed in a deep free-kick at the back post and then drilled home his second with 20 minutes left before Lucas da Cunha reduced the deficit with a late penalty.
Inter are now nine points clear of Napoli, who had earlier seen their five-game winning run come to an end with a 1-1 draw at Parma.
Gabriel Strefezza fired the home side ahead inside the opening minute, but Scott McTominay's 12th goal of the season had Antonio Conte's men level on the hour, leaving them three points in front of AC Milan in third.
Bologna recovered from their defeat by Aston Villa in the Europa League on Thursday night with a 2-0 win over relegation-battlers Lecce.
Genoa beat Sassuolo 2-1 with a late goal from Caleb Ekuban after both sides had been reduced to 10 men following a scuffle in the tunnel at the end of the first half.
Villarreal consolidated third spot in LaLiga with a 2-1 win at Athletic Bilbao, opening up a four-point lead over Atletico Madrid, who had slipped to a third straight league defeat at Sevilla on Saturday.
Improving Mallorca beat Rayo Vallecano 3-0 for a third win in four league games to climb out of the bottom three, while Oviedo boosted their own survival bid with a 3-0 victory at European hopefuls Celta Vigo.
Real Betis saw their winless league run stretch to seven games after being held to a 1-1 draw at Osasuna.
Stuttgart sit third in the Bundesliga after a 4-0 home win over Hamburg.
Cologne ran out 3-1 winners over 10-man Werder Bremen, who remain just three points above the relegation zone, and Freiburg beat Mainz 1-0.
Lille moved up into third in Ligue 1 with a 4-0 win at Toulouse after the home side saw defender Mark McKenzie sent off early in the second half, which was a fourth straight league victory for the visitors.
Lyon ended a nine-game winless run as they beat Lorient 2-0 to move back into fifth place, while Nice drew 1-1 with fellow relegation-battlers Le Havre.
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