The Dockers led by just eight points at half-time of Friday night's match before kicking 11 goals to one in the second half to race out easy 16.16 (112) to 6.6 (42) winners.
Amiss took seven marks inside 50m on the way to 5.1, while last year's Rising Star winner Murphy Reid (26 disposals, one goal) snared the Glendinning-Allan medal as best afield after turning the contest on its head with a mesmerising nine-possession third quarter.
Matthew Johnson (29 disposals, six clearances) and Caleb Serong (26 disposals, seven clearances) also had big games in front of 56,616 fans - a record home crowd for a Fremantle regular-season game.
There was late concern for West Coast mid-season recruit Oliver Francou when his right knee was gashed open by boot studs during a tackle on Andrew Brayshaw.
Eagles players immediately signalled to the bench for help as Francou lay on his back and lifted his leg high in the air to stop blood from gushing out.
Play was stopped for several minutes while Francou received treatment and was given a green pain whistle before he was stretchered off the ground.Â
Star West Coast midfielder Harley Reid battled hard on the way to 30 disposals, 12 clearances, while Tim Kelly (31 disposals, 603m gained) and defender Marcus Herbert (36 disposals) were prominent.
The Dockers have now won five derbies on the trot - and 10 of the past 11 - to close to within three in the overall head-to-head ledger (33-30).
The result means Fremantle (17-2) will finish the round at least three wins clear on top of the table with just four remaining, putting them in an excellent position to snare just their second minor premiership.
"They're a powerful team. It looked like they were five years advanced on us really, in every phase of the game," Eagles coach Andrew McQualter said.
"They were stronger. They were able to break our tackles tonight."
Freo dominated the inside 50m count 15-8 in the first term, but their wayward return of 2.6 allowed the Eagles to take a shock one-point lead into quarter-time.
Amiss cashed in with three goals in the second quarter - two of which came with him in plenty of space out the back - but a late goal to Eagles big man Jack Williams meant West Coast were only eight points down at halftime.
The contest was begging for a game breaker and it was Murphy Reid who delivered it during the third term.
Reid was running at pace when he used the outside of his boot to perfectly pick out Isaiah Dudley in the forward line. The resultant goal put Fremantle 21 points up.
A short time later, Reid completed a give-and-go before nailing a 50m shot on the run.
The lead was 40 points by the end of their five-goal blitz, with the Dockers continuing to pile on the pain after that on the way to an easy win.
"It was a dominant performance from start to finish," Dockers coach Justin Longmuir said.
"I thought a bit of inaccuracy cost us (early). We had eight more scoring shots at half-time, but we'd also blown a fair few other opportunities."
