Cameron Kite, 41, faced court for the first time on Monday charged over the death of 47-year-old Jarrad Antonovich at a health retreat.
Mr Antonovich died of a perforated oesophagus after consuming the plant-based psychedelic ayahuasca and frog-based poison kambo at the Arcoora retreat in northern NSW on October 16, 2021.
Kite is alleged to have been the leader of the ceremonial ritual where Mr Antonovich consumed the drugs.
The operator of the retreat, Soulore Solaris, was arrested and charged with manslaughter on March 5.
Solaris, formerly known as Peter George McIntyre, is also accused of delaying medical treatment for the 47-year-old after he collapsed.
Kambo is only found in the Amazon rainforest and is obtained by scraping the mucus-like substance off the back of a giant tree frog.
It is classified as a Schedule 10 poison by the Therapeutic Goods Administration, the highest level of classification, meaning it is completely banned from use.
Ayahuasca, banned in 2022, is a plant-based psychedelic normally consumed as a bitter-tasting "tea" with a strong odour.
The use of both substances is based on the traditional knowledge of indigenous South American communities, with adherents believing they can detoxify the body.
But some medical experts say there is no proof the substances do more than make people extremely ill.
15°C