It was not immediately clear what was behind the explosions about 2am on Saturday.
Venezuela's government, the Pentagon and White House did not immediately respond to requests for comment.
People in various neighbourhoods rushed to the streets.
Some could be seen in the distance from various areas of Caracas.
This comes as the US military has been targeting, in recent days, alleged drug-smuggling boats.
On Friday, Venezuela said it was open to negotiating an agreement with the United States to combat drug trafficking.
The South American country's President Nicolas Maduro also said in an interview aired on Thursday that the US wanted to force a government change in Venezuela and gain access to its vast oil reserves through the months-long pressure campaign that began with a massive military deployment to the Caribbean Sea in August.
Maduro has been charged with narco-terrorism in the US.
The CIA was behind a drone strike last week at a docking area believed to have been used by Venezuelan drug cartels in what was the first known direct operation on Venezuelan soil since the US began strikes on boats in September.
US President Donald Trump for months had threatened that he could soon order strikes on targets on Venezuelan land.
Iranian state television reported on the explosions in Caracas on Saturday, showing images of the Venezuelan capital.
Iran has been close to Venezuela for years, in part due to their shared enmity of the US.
with Reuters
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