Missiles rained down on the city of Dnipro and the surrounding region in the early hours of Friday, damaging residential buildings, the main train station and injuring at least 28 civilians, regional officials said.
Russia has stepped up its long-range aerial assaults on Ukraine's energy system and other targets in recent weeks, ratcheting up the pressure on Kyiv far behind the front lines where Russian forces have been slowly advancing in the east.
President Volodymyr Zelenskiy called for urgent supplies of air defences from Kyiv's allies as Ukraine's stocks dwindle due to a slowdown in vital Western military aid.
"Russia must be held accountable for its terror, and every missile, every Shahed (drone) must be shot down," he said.
At least 28 civilians were injured in the Russian attack, regional officials say. (AP PHOTO)
"The world can guarantee this, and our partners have the necessary capabilities."
In a first for Ukraine during the invasion, Kyiv's air force commander and military spy agency said they had shot down a Russian Tu-22M3 strategic bomber that had fired missiles at Ukraine during the overnight attack.
The warplane, they said, had been flying in Russian airspace 300km from the Ukrainian border.
An intelligence source told Reuters that Kyiv had used a modified S-200 air defence missile for the attack, but did not say where it had been fired from.
The S-200 is a Soviet-era long-range surface-to-air missile system.
The Russian defence ministry said the bomber had crashed in Russia's southern Stavropol region, hundreds of kilometres from Ukrainian-controlled territory, as it returned to base after carrying out a combat mission.
But it said the crash appeared to have been caused by technical malfunction.
The four Russian air force crew members ejected from the warplane; two were rescued, one died and a rescue operation was under way for the fourth, the Russian regional governor said.
Ukraine's air force said it shot down 15 missiles, including two Kh-22 cruise missiles and 14 drones during the overnight attack.
The Dnipropetrovsk region's governor Serhiy Lysak said air defences shot down 11 out of 16 missiles and nine out of 10 drones that attacked the region.
Prime Minister Denys Shmyhal put the death toll at eight.
Foreign Minister Dmytro Kuleba said a 14-year-old girl and 8-year-old boy had been killed.
A five-storey residential building in the city of Dnipro was badly damaged and fire fighters battled to put out a fire at the site early in the morning.
